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KMID : 0043319990220030300
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Archives of Pharmacal Research
1999 Volume.22 No. 3 p.300 ~ p.301
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Stereoselective Synthesis of (±)-Epibatidine Analog(±)-2β-(2-Chloro-5-pyridinyl)-8-azabicyclo[3.2.1]octane
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Kim Yong-Hyun
Won Do-Youn
Oh Chang-Young
Woo Nam-Tae
Park Young-Ho
Jeong Jin-Hyun
Ham Won-Hun
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Abstract
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Stereoselective synthesis of ()-epibatidine analog 2, which contains the 8-azabicyclo[3.2.1]octane ring system, was achieved by using palladium-catalyzed Heck-type coupling reaction from 3.
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KEYWORD
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Alkaloids, Analgesics, Palladium, Stereocontrol
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